Targeting the estrogen system to treat CNS-driven disease

University of Dundee

Past award

Student: Rebecca Crook : University of Dundee

Year Award Started: 2012

Numerous clinical studies indicate that cognitive impairments are prevelant in women following the menopause.
Reduced levels of the hormone estrogen are linked to these impairments and recent studies indicate that
estrogen markedly influences learning and memory. Thus estrogen-based therpaies may be useful in treating
cognitive decline in women. However our understanding of how estrogen influences brain function is limited. Here
we propose to examine the impact of different estrogen receptors on glutamate receptor trafficking: a key event
underlying learning and memory.

Research area: Neurological conditions (including stroke)


Dr Jenni Harvey
School of Medicine