Synthesis and phenotypic screening of novel anticancer kinase inhibitors

The project aims to provide the student with training in the fundamental techniques used for the preparation and biological screening of novel compounds, while at the same time will explore the development of small molecules of interest for the hosting lab. Specifically, the student will carry out the synthesis of novel derivatives of based on kinase inhibitors (so called lead compounds) discovered in the Unciti-Broceta’s lab. Novel compounds will be screened against cancer cell lines to in the search for either novel or improved pharmacological properties.