Is syk kinase implicated in psoriasis and psoriatic arthritis pathogenesis?

University of Glasgow

Past award

Student: Hayley Patterson : University of Glasgow

Year Award Started: 2012

There is much interest in finding new targets for the treatment of arthritis and skin diseases that are caused by
inflammation. Recently a new class of drugs entitled kinase inhibitors have been developed that have been very
effective in clinical trials in the treatment of rheumatoid arthritis. In particular a medicine called fostamatinib has
been shown to be effective in treating rheumatoid arthritis – this drug targets a particular molecule called syk
kinase. We will explore the presence and function of syk kinase in tissues derived from patients with psoriasis
and psoriatic arthritis to establish whether this might also be a valid target for application in these diseases in due

Research area: Infections, inflammation or immunology


Professor Iain McInnes
Institute of Infection, Immunity and Inflammation