SPLUNC1, the connection between low pH and mucous disfunction in Cystic Fibrosis?

University of Glasgow

Past award

Student: Ryan Wong : University of Glasgow

Year Award Started: 2015

SPLUNC1 is a protein found in the lungs and upper airways of humans and has multiple functions.
One of the functions of the protein is to keep the lungs lubricated and to prevent them from drying
out. In cystic fibrosis sufferers, SPLUNC1 does not work properly as their airways are too acidic, and
as a result the mucous in their lungs becomes dehydrated. The aim of the project is to identify why
SPLUNC1 doesn’t work in the acidic conditions of cystic fibrosis lungs to get a better understanding
of the disease.

Research area: Respiratory conditions


Dr Brian Smith
Institute of Molecular, Cell and Systems Biology