The relevance of poor glycaemic control to stroke outcome

University of Dundee

Past award

Daphne Jackson Fellow: Dr John Pexton

Year Award Started: 2017

Diabetic patients suffer an increased risk of stroke. One potential contributory mechanism may be that poor glycaemic control interferes with neuroprotective mechanisms. My host laboratory has developed a novel microfluidic model to study neurotoxicity and counterbalancing neuroprotective mechanisms in networks and discovered a new fast-acting neuroprotective activity operating at the level of the network. Preliminary evidence indicates that this network cooperation is compromised by hypoglycaemia, but the mechanism is unknown. This project provides a unique opportunity to investigate how neuronal responses (morphological changes, network functionality and the recruitment of neuroprotection) are compromised by altered glucose availability. Using this novel, in vitro microfluidic model, a greater scientific understanding of these processes can be rapidly developed. Potential therapeutic/neuroprotective approaches will then be validated using an in vivo middle cerebral artery occlusion (MCAO) model of stroke in both normal and diabetic rodents.

Research area: Neurological conditions (including stroke)


Dr Christopher Connolly
School of Medicine