Regulation of neuronal growth by tryptophan metabolites

University of Glasgow

Past award

Student: Susana Qasem : University of Glasgow

Year Award Started: 2014

We have found that a group of compounds generated from the amino acid tryptophan affect the early development of the brain in embryos. This project will use cell cultures to explore the mechanisms of this. Nerve cells will be cultured and exposed to five of the major kynurenine metabolites for at least 24h, after which the candidate will determine cell growth, proliferation rate and ability of the cells to follow molecular guidance cues and form connections. The results will add greatly to understanding factors that affect the earliest stages of brain formation.

Research area: Neurological conditions (including stroke)


Professor Trevor Stone
Institute of Neuroscience