Recombinant expression of beta-2-microglobulin in E.coli

University of Glasgow

Past award

Student: Julija Maldutyte : University of Glasgow

Year Award Started: 2016

Beta-2-microglobulin (B2M) is a protein that forms part of the MHC Class 1 molecule, a group of
molecules found on mammalian cells which help the body identify infected cells. B2M can be used to
increase the immunological potential of vaccines and producing it easily and cheaply would be very
beneficial. One such way could be using recombinant protein expression in bacteria, such as E.coli, to
make large quantities of high quality B2M cheaply and efficiently.

Research area: Infections, inflammation or immunology


Dr Cheryl Woolhead
Molecular, Cell and Systems Biology