A novel treatment for glioblastomas using platinum-cucurbituril based drugs delivered in a nasal insert formulation

In this project, we wish to develop a novel drug delivery system for the specific treatment of brain cancers. A dinuclear platinum drug (as a model for the clinical agent BBR3464) will be enclosed within a macrocycle called cucurbituril. This will then be formulated into nasal inserts, a novel method for delivering drugs that bypasses the blood-brain barrier. The performance of the nasal inserts will be examined to determine their drug release rates, solubility in simulated nasal fluid, stickiness to simulated muscosal membranes and their water absorption.