Investigating the role of phosphorylation in regulating KCC2 activity levels

GABA is a very important chemical in the brain whose function when disrupted contributes to the many nervous system disorders. Maintaining a proper balance in the levels and activity of this chemical is therefore important. In this context, the function of KCC2 is significant. Through its role in altering levels of chloride in the cell it has the ability to affect GABA function. Thus a variety of means have evolved to control KCC2 function and thereby alter GABA activity. This proposal will examine the role that phosphorylation of KCC2 at specific sites has in changing the strength of KCC2 action. The project has important implications for our understanding of how GABA may be controlled in the normal and diseased brain.