Heterogeneous hydrogels: Producing graded scaffolds for tissue-engineered musculoskeletal applications

The junctions between tissues of the musculoskeletal system have unique mechanical properties that are vital for normal function and movement. In particular, the interfaces between the soft tissue of tendon and the hard tissue of bone have a carefully constructed arrangement, forming a graded transition between the two tissues. This is largely achieved through an increase in mineral content from tendon to bone, with mineral providing increased mechanical properties across the transition. This project aims to investigate the formation of hydrogel scaffolds to mimic this transitional region and produce a tissue-engineered option to facilitate repair following tendon injury.