The guanidine group as a mitochondrial tag and its implications on drug function University of Dundee Past award Student: Paul Middleton : University of Dundee Year Award Started: 2012 Research on the chemical composition of biguanide antihyperglycaemics (metformin) and the similar diguanide compounds has suggested that an integral chemical group within these drugs (guanidine) directs these drugs to the mitochondria and is therefore a major component of their function. This project aims to prove that the guanidine group can selectively target molecules to the mitochondria and then assess the implications of the addition of this compound on existing pharmaceuticals and novel compounds. Research area: Metabolic or endocrine conditions Supervisors: Dr Graham Rena School of Medicine Back to all awards