The guanidine group as a mitochondrial tag and its implications on drug function

University of Dundee

Past award

Student: Paul Middleton : University of Dundee

Year Award Started: 2012

Research on the chemical composition of biguanide antihyperglycaemics (metformin) and the similar diguanide
compounds has suggested that an integral chemical group within these drugs (guanidine) directs these drugs to
the mitochondria and is therefore a major component of their function. This project aims to prove that the
guanidine group can selectively target molecules to the mitochondria and then assess the implications of the
addition of this compound on existing pharmaceuticals and novel compounds.

Research area: Metabolic or endocrine conditions

Supervisors:

Dr Graham Rena
School of Medicine