Functional outcome of GM-CSF mediated microglial activation in the central nervous system

University of Glasgow

Past award

Student: Andreea Croitoru : University of Glasgow

Year Award Started: 2017

The introduction of immunomodulatory treatments for multiple sclerosis (MS) revolutionized the clinical management of this devastating disease, but their efficacy remains limited by large numbers of non-responders and potentially serious side effects. Granulocyte-macrophage colony-stimulating factor (GM-CSF) is a protein that is attracting great interest as a novel therapeutic target for treatments designed to halt disease progression in MS. This project will investigate how GM-CSF contributes to disease development, focusing on how it promotes tissue destruction by microglial; a cell type that normally helps protect the brain and spinal cord from damage caused by viruses and other pathogens.

Research area: Neurological conditions (including stroke)


Professor Christopher Linington
Institute of Infection, Immunity and Inflammation