Evaluation of the osteoclasotgenic mechanisms that are altered by immunomodulation

University of Glasgow

Past award

Student: Sana Rintala : University of Glasgow

Year Award Started: 2012

Bone ersoion is a feature of many diseases including rheumatoid arthritis, osteoporosis and multiple myeloma.
The bone-eating cells (osteoclasts) responsible for this process, and the cells that they mature from, are found in
greater numbers in the diseased condition. Strategies that can target this aspect of the disease process are of
intense interest. We have recently found a therapeutic that can manipulate this process through the regulation of
the cellular pathways that control the fate of the precursors of osteoclasts. The proposed study will examine this
mechanisms underlying this regulation.

Research area: Musculoskeletal conditions


Dr Carl Goodyear
Institute of Infection, Immunity and Inflammation