The effect of statins on circulating microRNA in patients with hypercholesterolaemia

It is well known that increased levels of cholesterol in the bloodstream leads to its deposition in
veins causing complications including heart attacks. Patients with high cholesterol are commonly
treated with statins to lower cholesterol. Recent studies have shown that there is a significant
correlation between circulating cholesterol and specific microRNA. To date no studies have shown
whether these circulating microRNA are altered by statin therapy. The aim of this study is to
determine whether statins affect the levels of specific circulating microRNAs. MicroRNAs have
potential as therapeutic targets and may have a role in monitoring treatment in patients with
hypercholesterolaemia.