Characterising the reduction of methionine sulfoxide in the mammalian endoplasmic reticulum

This project aims to characterize the pathway of repair of methionine residues in proteins present in
the secretory pathway to provide a much greater understanding of the role of methionine oxidation
during oxidative stress. Oxidative stress can lead to debilitating diseases such as Alzheimer’s,
Parkinson’s and cancer so it is important for us to understand the how cells cope with the damage to
proteins caused under stress. One consequence of oxidative stress is the oxidation of proteins at
either methionine or cysteine residues. This oxidative damage can be repaired by enzymes that
reverse the modification. Our understanding of the repair to cysteine residues is well advanced;
however, our understanding of the repair of methionine residues is limited