Characterising the interaction of drug target mutants with host cells

University of Glasgow

Past award

Student: Karen Crokston : University of Glasgow

Year Award Started: 2012

We have previously found a group of drugs that interfere with how bacteria attach and infect human cells.
However, working out how these drugs work is difficult. One step forward has been to find out what the targets
of these drugs are. In this study we would like to see what happens to bacteria when we specifically remove one
of these drug targets and will see if the bacteria can still infect human cells. This is an important step forward in
understanding how these drugs work, which is essential if we want to make them even more potent. The longterm
aim is to make a new class of anti-infective compounds to use clinically


Dr Andrew Roe
Institute of Infection, Immunity and Inflammation