Characterisation of a novel mouse model of induced androgen receptor expression

In additon to its role in male fertility, emerging data has linked changes in testosterone action to increased risk of cardiovascular disease, diabetes, prostate-cancer and several age-related conditions in men. As part of our wider studies to address this, we have generated a unique transgenic mouse in which we can switch on or increase the testosterone signal in any cell-type. The aim of this eight week project is to characterise the reproductive tissues from these mice. Characterisation and validation of this model is an essential step towards further study of the key roles testosterone plays in mens lifelong health.