Research in Glasgow
We support research across all the fields of clinical, biomedical, physical or engineering sciences related to medicine. The following are awards made to researchers working in Glasgow's universities and hospitals.
Awards in 2012-13
Professor Iain McInnes (Centre of Immunobiology) will be supervising Brian Morton during his PhD Studentship, "The role of microRNA-155 as a master-switch determining the balance of inflammation and fibrosis in chronic disorders". This research will also involve close working with Lamellar Biomedical Ltd.
New molecules called microRNA (miR) have been discovered recently. They are safeguards of normal cell behaviour thus organ function. Their malfunction often leads to development of diseases: we discovered that too much of one of these molecules (miR-155) is associated with severe inflammation (e.g. arthritis). However, too little is associated with fibrosis (e.g. lung fibrosis). This project aims to find out how miR-155 works; and how it can be controlled as a new treatment strategy for arthritis and pulmonary fibrosis. The key cellular functions controlled by miR-155 will be studied in mouse models of arthritis or lung fibrosis as well as in cells taken from patients with arthritis and pulmonary fibrosis. In order to restore tissues' normal functions, we will bring back the proper levels of miR-155 in experimental arthritis and fibrosis using a new safe method of drug delivery developed by a Scottish biomedical company. We hope to discover the cell functions controlled by miR-155 and how they are associated with disease processes, and the feasibility of reversing tissue pathology by modifying miR-155. There is no effective therapy for lung fibrosis and treatment-resistant arthritis. Therefore our project may provide a novel way of controlling these diseases.
Undergraduate Vacation Scholarships were awarded as follows:
Dr Andrew Sutherland (School of Chemistry) will be supervising Nikki Sloan during her PhD Studentship "New Metal Catalysed Methods for the Efficient, Non-toxic Generation of PET and SPECT Tracers: Molecular Imaging of Neurological Disease". This research will also involve close working with GE Healthcare.
Radionuclide molecular imaging is increasingly used for the early diagnosis of both neurological diseases and cancer. However, the widespread application of this technology is being limited due to current methods of generating the imaging agents which can involve unstable, highly toxic precursors. In collaboration with GE Healthcare, this project will investigate new transiton metal-catalysed chemical processes that will allow simple, easy access to PET and SPECT tracers from readily available, non-toxic starting materials. In particular, the project will investigate the use of nickel catalysts for the incorporation of radiohalogens into aromatic compounds, structural motifs that are found extensively in molecular tracers. On development of each new reaction, the versatility of this process will be demonstrated by the preparation of molecular tracers used in the imaging of cancer and neurological disorders, particularly Alzheimer's disease. Discovery and successful development of these new chemical transformations for the non-toxic and facile preparation of PET and SPECT imaging agents will accelerate the application of this technology across the NHS and the pharmaceutical/life sciences industries.
Aimee Bias (Bioengineering, Glasgow University) supervised by Dr Aleksandra Vuckovic, for a project entitled, Motor imagery based brain computer interface for neurorehabilitation of the hand.
Andrew Burns (Chemistry, Glasgow University) supervised by Professor Sheila Graham, for a project entitled, Testing for cervical disease in liquid based cytology samples using a panel of viral RNA biomarkers.
Jordan Canning (Biomedical Science, Glasgow Caledonian University) supervised by Dr Xinhua Shu, for a project entitled, Creation of a human RPGR mini promoter for retinitis pigmentosa gene therapy.
Hayley Cassidy (Microbiology, Glasgow University) supervised by Dr Andrew Roe, for a project entitled, Bioluminescent labelling of Pseudomonas aeruginosa.
Fatima Chaudhry (Medicine, Cambridge University) supervised by Professor Mary Lumsden, at Glasgow University for a project entitled, A study on lifestyle risk factors, vascular reactivity and insulin resistance in in young women with polycystic ovaries of South Asian and European origin.
Rachael Davis (Medicine, Glasgow University) supervised by Professor Muriel Caslake, for a project entitled, The effects of high intensity interval training on cardiovascular biomarkers in conditioned, healthy and sedentary individuals.
Thomas Docherty (Biochemistry, Glasgow University) supervised by Professor Neil Bulleid, for a project entitled, Identification of proteins modified by nitrosylation in the mammalian endoplasmic reticulum.
Philip Emerson (Medicine, Glasgow University) supervised by Dr John Kinsella, for a project entitled, Liver cirrhosis and predictive scoring tools in critical care.
Aisha Ghaus (Medicine, Glasgow University) supervised by Dr Anna Freel, for a project entitled, Association between variation at CYP17A1 locus and steroid phenotype: a novel mechanism in essential hypertension?.
Kunzah Jamal (Molecular & Cell Biology, Glasgow University) supervised by Dr Helen Wheadon, for a project entitled, Evaluating patient derived induced pluripotent stem cells (iPSC) for drug screening.
Dimitar Karadzhov (Psychology, Glasgow University) supervised by Professor Joachim Gross, for a project entitled, Investigating the neural basis for checking, selective attention, and working memory in obsessive compulsive disorder, through MEG and TMS.
Ariadni Kouzeli (Immunology, Glasgow University) supervised by Dr Simon Milling, for a project entitled, Characterisation of IL-23-producing cells in patients with spondyloarthritis.
Catriona McDonald (Anatomy, Glasgow University) supervised by Dr Emily Ord, for a project entitled, Impact of miRNA modulation on cerebral cells in an in vitro model of hypoxia reoxygenation.
Alise Molotova (Genetics, Glasgow University) supervised by Dr Carl Goodyear, for a project entitled, Evaluation of recombinant molecules for modulation of the myeloid compartment.
Louise Nugent (Biomedical Science, Glasgow Caledonian University) supervised by Dr Catherine Wright, for a project entitled, Cell-cell communication and death in diabetic skin wound healing models.
Anastasia Pesic (Pharmacology, Glasgow University) supervised by Dr Laura Denby, for a project entitled, Examination of the role of exosomal miRNA in cell:cell communication in the kidney.
Hanna Rooslien (Psychology, Glasgow University) supervised by Professor Stephany Biello, for a project entitled, Sleepless in Glasgow: How do homeostatic sleep mechanisms interact with the circadian timing system?.
Semjon Sidorov (Immunology, Glasgow University) supervised by Dr Charles McSharry, for a project entitled, Is steroid-refractory asthma among cigarette smokers mediated by activation of the aryl-hydrocarbon receptor?.
Sara Wagner Valladolid (Neuroscience, Glasgow University) supervised by Dr Guillaume Rousselet, for a project entitled, Modelling 3D dynamic mental representations of facial expressions of emotion in the ageing brain.
Ruaridh Winstanley (Biomedical Engineering, Glasgow University) supervised by Dr Henrik Gollee, for a project entitled, Ultrasound feedback for diagnosis and rehabilitation in neurological disease .
On Fai Arthur Woo (Medicine, Glasgow University) supervised by Dr Emilie Combet, for a project entitled, Studying the impact of ageing and disease on the colonic metabolism of dietary phytochemicals using advanced models of colonic fermentation.
Hannah Wright (Electrical & Mechanical Engineering, Strathclyde University) supervised by Dr Anthony McClusky, for a project entitled, Development of microfluidic devices for use in personalised medicine research on cancer biopsies.
Awards in 2011-12
£149,790 over three years to Dr Leanne McKay (Institute of Neuroscience & Psychology, Glasgow University), to study the development and maturation of the neural control of breathing.
Dr Brian Smith (Institute of Molecular, Cell & Systems Biology) will be supervising Miss Karen McClymont during her PhD Studentship, "Characterisation of a molecular switch: how does Factor C recognise, and change shape in response to endotoxin? Towards a sensitive synthetic endotoxin test". This research will also involve close working with Marine Biotech Ltd.
Complications in some bacterial infections can prove fatal as a result of the actions of endotoxins, derived from the components of certain bacteria. Discovering ways to detect and neutralise toxic challenges are vital to ensuring the safety of drugs, medical devices and vaccines. Horseshoe crab blood components are used for the compulsory safety testing of all pharmaceutical injectable products and medical devices. Horseshoe crab blood is used because a blood protein Factor C recognises endotoxins at an infection site and then elicits a chain of events which leads to both inactivation of the bacteria and wound healing. The detail of this process is not well understood, so will be investigated with the aim of using the knowledge gained to develop a synthetic testing system based on Factor C to provide a robust endotoxin detection test. Such properties could also form the basis for development of future therapeutics in endotoxin-compromised patients. Producing a low-cost higher quality alternative to the existing endotoxin test to reduce both the risk of contamination and the price of drugs to the NHS and would also represent a significant advancement in medical technology.
Respiratory control disorders like sleep apnoea and sudden infant death syndrome are very common, but their origins are not well understood. A better understanding of how the brain generates the nerve signals that produce respiratory rhythm is crucial if ways are to be found to treat or prevent these disorders. This project aims to provide valuable new information about the mechanisms underlying development and maturation of the respiratory system.
Undergraduate Vacation Scholarships were awarded as follows:
Ms Sana Rintala (Immunology, Glasgow University) supervised by Dr Carl Goodyear, to evaluate the osteoclasotgenic mechanisms that are altered by immunomodulation.
Ms Hayley Patterson (Immunology, Glasgow University) supervised by Professor Iain McInnes, to investigate whether syk kinase is implicated in psoriasis and psoriatic arthritis pathogenesis.
Ms Kunza Jamal (Biochemistry, Glasgow University) supervised by Dr Daniel Walker, to study the production and characterisation of novel pyocins active against Pseudomonas aeruginosa.
Ms Anna Price (Statistics, Glasgow University) supervised by Dr Jackie Price at Edinburgh University, to study the potential of plasma N-terminal pro B-type natriuretic peptide (NT-proBNP) as a marker of cardiovascular risk in people with type 2 diabetes/
Ms Holly Morrison (Immunology, Glasgow University) supervised by Professor Gerard Graham, to examine the functional importance of CCR10 upregulation on neutrophils by TLR ligands.
Ms Karen Crokston (Microbiology, Glasgow University) supervised by Dr Andrew Roe, to characterise the interaction of drug target mutants with host cells.
Ms Linn Olsen (Psychology, Glasgow University) supervised by Dr Stephanie Rossit of Glasgow Caledonian University, when she studied the relationships between eye movement deficits and lesion locations in stroke patients.
Mr Bartlomiej Kulka (Biochemistry, Glasgow University) supervised by Dr Brian Smith to study whether the endotoxin binding domains of Factor C cooperate in endotoxin binding.
Ms Amanda Trimble (Veterinary Medicine, Glasgow University) supervised by Dr John Marshall to analyse peritoneal fluid serum amyloid A (SAA) as a predictor of survival in equine colic.
Awards in 2010-11£120,229 over 24 months to Dr Paul Hoskisson (Institute of Pharmacy & Biomedical Sciences, Strathclyde University), for a study of non-toxigenic Corynebacterium diphtheriae - a pathogen of emerging importance in Scotland.
Diphtheria is a debilitating disease of the throat and pharynx caused by the bacterium Corynebacterium diphtheriae. Although relatively rare in the UK thanks to an effective vaccine, it remains a common childhood illness in the developing world. Recent increases in cases where there is serious, persistent infections of the throat, bones and heart have, however, highlighted a lack of understanding of the detailed disease mechanisms. This research aims to rectify this deficit and point the way to developing new treatments or improved vaccines.
£141,848 over 30 months to Dr Hui-Rong Jiang (Institute of Pharmacy & Biomedical Sciences, Strathclyde University), to investigate IL-33 activity in the development of neurological autoimmune diseases.
Multiple sclerosis (MS), a chronic disease which causes irreversible damage to the central nervous system (CNS), is the leading cause of non-traumatic neurological disability among young adults and its prevalence in Scotland is one of the highest in the world. There is currently no cure and existing treatments are largely ineffective. MS is an autoimmune disease in which cell-signalling proteins called cytokines play an important part. This project aims to improve understanding of the role of cytokine IL-33 in the development of MS and other neurological diseases by clarifying its role in modulating immune responses and CNS repair.
£74,192 over 18 months to Dr Annette Sorensen, Dr Marie Boyd & Dr Anthony Mcclusky (Strathclyde Institute of Pharmacy & Biomedical Sciences, Strathclyde University) for an 18-month investigation of novel combination therapies for the treatment of medulloblastoma and other somatostatin receptor expressing tumours.
Medulloblastoma is the most common type of brain tumour affecting children. Current treatments for it and other similar cancers have serious side-effects resulting from 'collateral' damage to the surrounding healthy tissues. This project will study a number of possible options for improved and more effective treatment.
Undergraduate Vacation Scholarships were awarded as follows:
Ms Karen Lai (Pharmacology, Strathclyde University) supervised by Dr Nial Wheate, to investigate a novel treatment for glioblastoma using platinum-cucurbituril-based drugs, delivered in a nasal formulation.
Mr Eric Cruickshank (Immunology, Glasgow University) supervised by Dr Carl Goodyear, to investigate the epigenetic regulation of osteoclast differentiation.
Ms Siobhan Hay (Pharmacology, Glasgow University) supervised by Dr Rachel Shirley, to study levels of apoptosis following cerebral ischaemia.
Awards in 2009-10£148,940 over three years to Dr Carl S. Goodyear (Clinical Neurosciences), Professor Margaret Harnett (Immunology, Infection & Inflammation, Glasgow University) & Dr Richard Soutar (Haematology, Gartnavel General Hospital, Glasgow) to study the inhibition of osteoclastogenesis by immunomodulatory complexes. (The Vipiana Award)
The bone destruction associated with gum disease, rheumatoid arthritis, osteoporosis and many other diseases, is caused by 'bone-eating' cells (osteoclasts) and the cells from which they mature. Normally, the body keeps the levels of osteoclasts and 'bone-making'cells (osteoblasts) roughly in balance. In the disease state, however, levels of osteoclasts are high and finding ways to reduce or prevent this rise are being sought. This project will study the detailed effects of a new protein complex, known to inhibit osteoclast maturation, on its ability to destroy bone.
£135,287 over 24 months to Dr Christine M. Dufes (Strathclyde Institute of Pharmacy & Biomedical Sciences) and Professor Kevin Ryan (Beatson Institute for Cancer Research, Glasgow) for the evaluation of systemic p73 gene therapy of cancer, using a novel transferrin-targeted dendrimer.
The potential for using gene therapy in cancer treatment is currently limited by the inability get the modified genes to deep-seated tumours efficiently and without healthy tissues being damaged in the process. This project aims to improve the efficiency of these 'seek and destroy' therapies by using an iron-targeted delivery system to carry the tumour-suppressor gene p73, directly to the tumour. Iron is essential for tumour cell growth and the tumour cells have many iron-carrier receptors on their surface. The hope is that intravenously-administered iron-targeted carriers will prove to be ahighly effective and specific means of anti-cancer treatment.
£150,000 over 36 months to Dr Colin Berry (Scottish Senior Clinical Research Fellow, BHF Glasgow Cardiovascular Research Centre, Glasgow University) to gain new pathological insights and functional significance using cardiac MRI in acute myocardial infarction.
Heart attack is the leading cause of premature ill health and death in Scotland and worldwide. It is a particular problem because it is difficult to predict and also the nature and severity of damage to the heart is difficult to detect. Echocardiography is often carried out immediately after a heart attack, to give doctors an indication of the functionality of the heart. But it cannot indicate any swelling or bleeding, so the true extent of the heart damage is not known. Magnetic Resonance Imaging (MRI), is the gold standard way to measure heart function, providing images of the beating heart, is non-invasive and, unlike a CT scan, does not involve harmful X-rays, so is safe to use and repeat - even in heart-attack patients. This project is developing new computer models of heart attack and combining them with the power of MRI scans, aiming to find better ways to prevent or treat heart attack in the future.
Undergraduate Vacation Scholarships were awarded as follows:
Ms Roisin Brown (Medicinal Chemistry, Strathclyde University) supervised by Dr Nial Wheate, for work investigating new methods to target delivery of anti-cancer drugs.
Ms Laura Castle (Medicine, Glasgow University) supervised by Dr Colin Berry, to assist in validating the use of cardiac MRI in the diagnosis of heart disease.
Mr Andrew Hutton (Immunology, Glasgow University) supervised by Dr Carl Goodyear, to investigate aspects of the immune system processes which result in bone destruction in rheumatoid arthritis.
Mr Niklas Janisch (Microbiology/Genetics, Glasgow University) supervised by Dr Daniel Walker, on a project investigating antibiotic-resistant strains of the bacterium Pseudomonas aeruginosa.
Ms Lucy King (Genetics, Glasgow University) supervised by Dr Andrew Roe, to study aspects of selected mutants of strains of the bacterium E. coli O157.
Awards in 2008-09£85,219 over 19 months to Dr Andrew J. Roe (Infection & Immunity) & Dr Richard Burchmore (Functional Genomics Facility), University of Glasgow, for the identification of proteins targeted by salicylic aldehyde inhibitors in Escherichia coli 0157.
Scotland has the highest rate in Europe of infection with the bacterium E. coli 0157, which causes serious disease, particularly in the very young and the elderly. This project aims to identify the proteins involved in the processes used by the bacterium to enable it to attach itself to the gut wall and also to understand better how they work. The results should provide pointers to the development of compounds which could be used to block the attachment of E. coli O157 to the wall of the gut and thereby reduce disease.
£145,332 over three years to Dr Nial J. Wheate, Dr Oliver Sutcliffe & Professor David Flint (Strathclyde Institute of Pharmacy & Biomedical Sciences, Strathclyde University), to investigate the mechanisms of folic acid-directed delivery of platinum(II)-based anticancer drugs using PAMAM dendrimers.
Cancers of the head, neck, ovarian, testicular, colorectal, lung and bladder are mainly treated with three platinum-based drugs. However, all three have severe side-effects (like nausea and vomiting), resulting from the drugs' indiscriminate attack on normal, as well as cancerous cells. These effects limit the amount of drug that can be given and the cancers themselves also develop resistance to platinum-based drugs, so patients relapse. This project aims to improve the efficacy of platinum drugs by investigating whether attaching them to the surface of tiny polymers and then to folic acid, allows the cancerous cells to be targeted more specifically.
£112,252 over two years to Dr Daniel Walker (Division of Infection & Immunity, Glasgow University), to study of the antimicrobial activity of novel protein antibiotics against Pseudomonas aeruginosa in the biofilm state.
Persistent lung infection with the bacterium Pseudomonas aeruginosa is the major cause of death in cystic fibrosis. The bacterium is naturally resistant to many commonly used antibiotics and acquires resistance to others,making infections very difficult to treat. New therapies are needed urgently. In cysitic fibrosis P. aeruginosa can grow as a thin film in the lungs and in this 'biofilm' state, is virtually impossible to eradicate with conventional antibiotics. This project aims to isolate protein antibiotics (pyocins) and investigate their ability to prevent the formation of P. aeruginosa biofilms and kill bacteria in existing biofilms.
£139,339 over two years to Dr Pasquale Maffia & Dr James Brewer (Strathclyde Institute of Pharmacy & Biomedical Sciences, Strathclyde University), for the visualisation of antigen presentation in models of atherosclerosis.
Cardiovascular diseases are the most common causes of death in Scotland and are expected to be the main cause of death globally within the next 15 years. New strategies for prediction, prevention, and treatment are needed. Immune responses are known to be important in atherosclerosis ('hardening' of the blood vessels), but the detailed mechanisms remain unknown. Using state-of-the-art technology (multiphoton microscopy) in animal models, this project will, in real time, investigate the detail of all the components of the immune response. The aim is to provide the detail needed to improve current therapeutic approaches and reduce cardiovascular morbidity and mortality.
Awards in 2007-08£106,114 over two years to Dr Shauna E. Culshaw (Centre for Biophotonics, University of Strathclyde) and colleagues Professor Paul Garside, Dr John Girkin, Professor Gail McConnell & Dr James Brewer (all of the Centre for Biophotonics, University of Strathclyde), to improve understanding of the basic mechanisms of the adaptive immune response to cariogenic bacteria in the oral cavity.
Oral health is a major component of general health, well being and quality of life. The social and economic costs of poor oral health are significant, but will only be reduced when new ways are found to prevent or treat the underlying dental decay. This fundamental study of the immune response to dental caries-causing bacteria aims to provide pointers to the best way forward.
£149,841 over three years to Drs Mary Donaldson & Iain Morgan (Department of Pathological Sciences, University of Glasgow Veterinary School), to investigate the potential of TopBP1 to be a therapeutic target for human papillomavirus infection.
This project aims to improve understanding of how proteins and other cell components interact with viral proteins, specifically the human papillomavirus (HPV) which causes genital warts and cervical cancer. The aim is to find ways to disrupt the life cycle of the virus so it cannot cause disease. The new vaccines only prevent initial infection with HPV; people already infected might still develop cancer and there is currently no way to prevent this.
The second Mrs Mary Tyson Fellowship was awarded to Dr Anna Sutherland (Department of Psychological Medicine, University of Glasgow) for her project entitled: "Perceived interpersonal threat as a unifying psychological model in Cluster B personality disorder".
Personality disorders are particularly difficult to treat and have significant social and economic costs. The aim of this project is to develop an effective, evidence-based cognitive model to improve clinical intervention aimed at reducing the antisocial and self-harming behaviours characteristic of these personality disorders.
Awards in 2006-07£79,111 to Dr Trevor John Bushell (Physiology & Pharmacology, University of Strathclyde) for a two-year project to determine the role of proteinase-activated receptor 2 upregulation in CNS neurones.
This study aims to understand the part played by proteinase-activated receptors in communication between nerve cells in the central nervous system, information that is key to the development of treatments for diseases such as multiple sclerosis, Alzheimer's and Parkinson's.
£80,000 to Dr Christopher Michael Loughrey (Cell Sciences, Veterinary Medicine, University of Glasgow) & Professor Godfrey Smith (Biomedical & Life Sciences, University of Glasgow) for a two-year investigation of the role of intracellular calcium in left ventricular diastolic dysfunction.
The heart's ability to pump blood through the body and then refill again is partly dependent on the action of calcium stored in the heart muscles. In 'heart failure' the heart cannot relax sufficiently for filling. This project will investigate whether the cause is a change in how the calcium works.
£79,816 to Dr Julie Calvert (Vision Sciences, Glasgow Caledonian University) & Professor Gordon Neale Dutton (Royal Hospital for Sick Children, Glasgow) for a two-year project on the identification, characterisation and management of dorsal stream dysfunction in children.
Many children with early brain damage have complex visual problems which may result from damage to the nerve pathway which processes information on the spatial properties and motion of objects. This project aims to develop a test to identify affected children as early as possible, to avoid their educational and social development being impaired.
Awards in 2005-06£79,252 over two years to Dr Patricia Martin (Biological & Biomedical Sciences, Glasgow Caledonian University) & Dr Malcolm Hodgins (Cancer Sciences & Molecular Pathology, Glasgow University) to investigate the therapeutic benefits of gap junction inhibitors in chronic wound-healing events.
Wounds which do not heal properly (chronic non-healing wounds) are a major health problem, particularly in an ageing population. This study will investigate whether altering the levels of a small protein involved in the intracellular communication essential to normal wound repair processes, could improve wound healing.
£77,636 to Dr Sally L. Pimlott (Department of Clinical Physics, University of Glasgow) & Dr Andrew Sutherland (Department of Chemistry, University of Glasgow) for a two-year project to develop a molecular imaging tracer for the noradrenaline transporter.
Noradrenaline is one of the substances in the brain that allow signals to pass from one nerve to another. At present, no suitable tracer molecule exists to enable the study of noradrenaline in brain disorders, or in some types of cancer treatment. This project aims to develop a new tracer, use of which will lead to better understanding of the processes involved.
Awards in 2004-05£79,807 over two years to Drs Robert Nibbs (Immunology), Dilys Freeman (Maternal & Reproductive Medicine), Professors Gerard Graham (Immunology) & Ian Greer (Obstetrics & Gynaecology, Glasgow University) for an investigation of the role of the chemokine receptor D6 in placental dysfunction.
Certain problems during pregnancy, such as the life-threatening pre-eclampsia, are caused by inflammation which damages the placenta. This study aims to investigate the potential for finding a biochemical means of controlling pre-eclampsia and other forms of placental dysfunction.
£60,537 over one year to Dr Mozheh Zamiri & Professor Colin Munro (Dermatology, Southern General Hospital, Glasgow) and Dr Malcolm Hodgins (Dermatology, Glasgow University) for research aimed at moving towards a comprehensive resource for elucidating the pathogenesis of inherited keratodermas.
Keratodermas are a rare inherited disorder which affects the metabolism of skin and results in painful areas of thickened skin on the palms of the hands and soles of the feet. This project will use a bank of patient tissues to identify cell markers which might be useful as targets for drug treatment.
Awards in 2003-04£79,644 to Dr Fiona A. White (Division of Clinical Neurosciences, Glasgow University) for a two-year project for the assessment of GADD34 as a potential therapeutic target in cerebral ischaemia.
This work aims to improve understanding of the molecular and cellular processes involved in the damage to brain cells which can result in stroke.
£75,394 over 18 months to Dr Amanda MacCallum (Institute of Comparative Medicine, Veterinary Pathology, Glasgow University), for an investigation of the early cell-signalling events in Campylobacter jejuni-infected enterocytes.
Campylobacter jejuni is the commonest cause of bacterial food poisoning in the western world and this work aims to clarify exactly how the bacterium enters cells in the gut and multiplies, resulting in disease.
£77,630 over two years to Drs Pamela Johnston, Chris Woodall & Penelope Redding (School of Life Sciences, Glasgow Caledonian University) for an investigation of control measures to limit norovirus infections in a hospital environment.
This work aims to investigate ways of inactivating the highly infectious norovirus which causes the gastrointestinal disease known as 'winter vomiting' and is prevalent in hospitals and care homes for the elderly.
The Mrs Jean V. Baxter Medical Research Fellowship 2004-06 was awarded to Dr Linda Scobie (Veterinary Pathology, Institute of Comparative Medicine, Glasgow University) to continue her work on the control of human trophic replication competent porcine endogenous retroviruses (PERV) in cells and organs for xenotransplantation.
Awards in 2001-02£60,594 over two years to Dr Linda Scobie (Veterinary Pathology, Glasgow University) for an analysis of full-length integrated porcine endogenous retroviruses and their infectious potential in xenotransplantation.
Being able to engineer organs in pigs which are suitable for human transplantation has the potential to save many lives. This research aims to identify the numerous viruses found in pigs which would otherwise make such transplants too dangerous.
£64,813 over two years to Dr Stephen J. Yarwood (Division of Biochemistry & Molecular Biology, Glasgow University) to investigate the role of EPAC proteins in inflammatory responses.
The protein EPAC is activated by cAMP, which has anti-inflammatory properties. As inflammation is the basis of numerous disorders, manipulating EPAC could prove a possible mechanism for new anti-inflammatory treatments.
£ 64,995 over two years to Dr James M. Brewer (Division of Immunology) and Drs Clive Bate & Alun Williams (Veterinary Pathology, Glasgow University) for an analysis of the role of cholesterol-sensitive domains in the trafficking and neurotoxicity of prions.
Prion diseases,such as CJD and BSE, cause death and dysfunction of neurones through mechanisms which are not fully understood. This study will look at the role of cholesterol-rich areas on neurones to establish if high levels of cholesterol are needed by prions to exert their destructive effects.
£64,839 over two years to Drs Winifred Boner & Iain Morgan (Veterinary Pathology, Glasgow University) for the characterisation of human papillomavirus 16 E2 cellular interacting proteins as therapeutic agents for treatment of HPV-related disease.
The life-cycle of the human papillomaviruses (HPV) is dependant on the E2 protein. Given the severity of diseases they cause and the lack of therapies, this research seeks to disturb E2 function to disrupt the viral life-cycle with molecules which could be therapeutic.
£58,637 over one year to Dr Jonathan T.O. Cavanagh (Psychological Medicine, Glasgow University), Professor David Wyper & Dr Jim Patterson (Clinical Physics, Southern General Hospital, Glasgow) for a SPECT study of the ratio of dopamine transporter to serotonin transporter in treatment-resistant compared with treatment-responsive depression.
In up to 30% of cases, depression is resistant to conventional treatment. This research will study the ratios of uptake of the neurotransmitters dopamine and serotonin in the brains of treatment-responsive and resistant depression to understand how the brain responds.
The Mrs Robina Menzies Medical Research Scholarship 2002-03 was awarded to Dr Kirstyn Brogan (Obstetrics, Queen Mother's Hospital, Glasgow) to investigate the role of sonembryology and maternal serum biochemistry in assessing the first trimester fetus at risk from chromosomal abnormalities.
Awards in 2000-01£69,720 over two years to Dr Paul H. Everest (Veterinary Pathology, Glasgow University) for the identification of Salmonella enteritidis genes required for colonisation and survival in poultry and shell eggs.
Salmonella enteritidis is a major cause of bacterial food poisoning. This research seeks to identify the genes which are needed for the Salmonella bacteria to colonise and then survive in poultry and shell eggs.
£69,217 over two years to Drs Robin J. Plevin (Physiology & Pharmacology) & Dino Rotondo (Immunology, Strathclyde University) to study the regulation of cell-selective cytotoxicity by verotoxigenic infective E. coli O157 and, in particular, H7 cellular signalling cascades as novel sites for drug intervention.
E. coli O157 causes severe intestinal problems and is a highly infectious bacterium for which antibiotic treatment is largely ineffective as the effects are mediated by verotoxins. However, as not all body cells are equally affected by the toxins, this research will study the effects in different cell types.
£69,967 over two years to Drs Craig W. Roberts & James Alexander (Immunology, Strathclyde University) to develop a rational molecular approach to designing a vaccine against congenital toxoplasmosis.
There is currently no vaccine for congenital toxoplasmosis, a protozoal infection which can cause serious disease. This research aims to identify proteins with a strong immunological response, with a view to designing a vaccine.
£70,000 over two years to Drs Sean Carlin & Robert J. Mairs and Professor Anne Barrett (Radiation Oncology, Glasgow University) for the development of radioiodide-based therapeutic strategies for the treatment of malignant disease.
Certain cells, including breast cancer and thyroid cells, are known to be able to take up iodine. Treatment of thyroid tumours has been improved by the use of radioiodide and this research intends to establish if this mechanism could also bring benefits in breast cancer treatment.
£69,921 over two years to Drs Winifred Boner & Iain Morgan (Veterinary Pathology, Glasgow University) for the development of an HPV16 E2-interacting protein as a therapeutic target for interfering with the viral life cycle.
The life-cycle of the human papillomaviruses (HPV) is dependant on the E2 protein. Given the severity of diseases they cause and the lack of therapies, this research seeks to disturb E2 function to disrupt the viral life-cycle with molecules which could be therapeutic.
The Cruden Medical Research Scholarship 2001-02 was awarded to Dr Gregor M. Walker (Neuroscience & Biomedical Systems, Glasgow University) for the determination of the role of superoxide dismutase in persistent pulmonary hypertension of the newborn.
Awards in 1999-2000£84,954 over two years to Dr Gurman Pall, Professor Keith Johnson & Dr Catherine Winchester (Molecular Genetics, Glasgow University) for the identification and characterisation of the genes regulated by the homeodomain protein SIX5 and their contribution to the pathogenesis in myotonic dystrophy.
£69,961 over two years to Dr Robert Aitken (Infection & Immunity) and Dr Brian L. Jones (Microbiology, Glasgow University) for the development of recombinant immunotheraptutics against Clostridium difficile.
£42,647 over two years to Dr Paul Neary (Medical Cardiology) & Professor Godfrey Smith (Biological & Life Sciences, Glasgow Unviersity) to investigate the characteristics of spontaneous SR Ca2+ release in failing human myocardium.
£68,457 over two years to Dr Stephany M. Biello (Psychology, Glasgow University) for a study of the neural basis of circadian timing.
£69,045 over two years to Dr Iain B. McInnes (Centre for Rheumatic Diseases, Glasgow Royal Infirmary) & Dr Jeremy H. Brock (Immunology & Bacteriology, Glasgow University) for a study of lactoferrin-mediate resistance to Staphylococcus aureus infection.
£69,847 over two years to Dr Marie Boyd (Radiation Oncology), Professor S. Moira Brown (Neurovirology), Dr Robert J. Mairs (Radiation Oncology), Dr Wilson Angerson (Surgery) & Professor Tom Wheldon (Radiation Oncology, Glasgow University) for an in vitro assessment of a new treatment for glioma combining virally-mediated cell lysis with gene transfer and targeted radiotherapy.
£69,321 over two years to Dr Janice Spencer, Dr Alun Williams & Professor Mark Roberts (Veterinary Pathology, Glasgow University) for a study of host-pathogen interactions during colonisation of preferred microenvironments by verocytotoxogenic Escherichia coli O157:H7 in young and adult cattle.
£69,162 over two years to Drs Thomas R.J. Evans, J. J. Going, Mr R. C. Stuart & Dr W.N. Keith (CRC Medical Oncology, Glasgow University) to study the senescence-like state of human oesophago-gastro cancers and its implication for response to cancer therapy.
£31,293 over three years to Dr Stuart R. Cobb (Neurosience & Biomedical Systems, Glasgow University) to investigate the role of nicotinic acetylcholine receptors in controlling epileptiform activity.
The Nasmyth Travelling Research Scholarship 2000-2002 was awarded to Dr Tracey A. Baird (Specialist Registrar, Neurology, Southern General Hospital, Glasgow) to visit the Department of Neurology, Royal Melbourne Hospital and the Centre for Brain Imaging Research, Austin & Repatriation Medical Centre, Heidelberg, Victoria, Australia.
The focus of Dr Baird's research is to find new, simple and cost-effective ways to diagnose and treat acute stroke - a disease which remains the third commonest cuase of dealth in Scotland.
Awards in 1998-99£68,952 over two years to Professor Timothy Mitchell & Dr John Coote (Infection & Immunity, Glasgow University) and Mr Stuart Clarke (Microbiology, Stobhill Hospital, Glasgow) for a study of the role of RTX proteins in the pathogenesis of disease caused by Neisseria meningitidis and their potential as vaccine molecules.
£63,819 over 18 months to Drs Naveed Sattar (Biochemistry, Glasgow Royal Infirmary), Jane Ramsay & Alan Mathers (Glasgow Royal Maternity Hospital), William Ferrell (Medicine, Glasgow Royal Infirmary) and Professor Ian A. Greer (Obstetrics & Gynaecology, Glasgow University) for direct assessemnt of microvascular function in pre-eclampsia using laser Doppler imaging.
£18,587 for a one-year project to Drs Andrew J. Thomson, Jane E. Norman and Professor Ian A. Greer (Obstetrics & Gynaecology) and Miss Marshia Crawford (Molecular & Cellular Biology, Glasgow University) to study the role of leucocytes in term and pre-term labour.
The Mrs Jean V. Baxter Medical Research Fellowship 1999-2002 was awarded to Dr Sophie V. Barrett (Beatson Oncology Centre, Western Infirmary Glasgow) to investigate mismatch DNA repair and drug resistance of breast tumours.
A one-year Medical Research Scholarship 1999-2000 was awarded to Dr Scott M. Nelson (Queen Mother's Hospital, Glasgow) to identify prognostic indicators of pulmonary hypoplasia in fetal congenital diaphragmatic hernia and obstructive uropathy.
Awards in 1997-98£15,170 over two years to Dr Charles Deehan (Beatson Oncology Centre, Western Infirmary Glasgow), Dr Thomas E. Wheldon (CRC Beatson Laboratories, Glasgow University) and Professor Alex T. Elliott (Clinical Physics, Western Infirmary Glasgow) for radiobiological modelling of new strategies for clinical radiotherapy.
£61,416 over 18 months to Dr Mark E.S. Bailey & Professor Keith J. Johnson (Division of Molecular Genetics) and Dr Alison Kerr (Psychological Medicine), Drs Goran A. Jamal & Peter Oketa-Onyut Julu (Neurology, Glasgow University) for an investigation of GABAa receptor subunit genes on the X chromosome ascandidates in Rett Syndrome (Dr Bailey was also awarded the Cruden Scholarship as part of the funding for this project).
£60,092 over two years to Dr W. Nicol Keith (CRC Medical Oncology), Dr James J. Going (Pathology) and Mr Robert C. Stuart (Surgery, Glasgow University) to investigate the role of telomerase expression and replicative ageing in Barrett's oesophagus.
£98,855 over three years to Drs Allan Mowat & Paul Garside (Immunology, Glasgow University) to investigate cellular mechanisms of bystander tolerance induced by oral administration of antigen.
Awards in 1996-97£9,935 to Dr Jane Norman and Professor Ian Greer (Obstetrics & Gynaecology, Glasgow Royal Infirmary, Dr Isobel Walker (Haematology, Glasgow Royal Infirmary) and Dr Alan Cameron (Obstetrics & Gynaecology, Queen Mother's Hospital, Glasgow) for a one-year study of the possible association of Factor V Leiden with recurrent miscarriage.
£68,806 to Professor Alison M. Gurney (Physiology & Pharmacology, Strathclyde University) for a two-year study aimed at developing a fluorescent assay for drugs that modulate pulmonary artery potassium channels.
£69,952 to Dr Jane Norman, Professor Ian Greer, Dr John A. Harper & Dr Charles B. Lunan (Obstetrics & Gynaecology, Glasgow Royal Infirmary) for a two-year study of the role of nitric oxide in human cervical ripening.
£69,954 to Professor Foo Y. Liew (Immunology, Glasgow University) for a two-year project involving the cloning of molecules on T cells inducible by IL-15 but not by IL-2 in rheumatoid arthritis using differential display and suprression subtractive hybridisation.
£50,818 to Drs Christopher Deighan & J.M. Boulton-Jones (Renal Unit) and Professor Christopher Packard and Dr M. Caslake (Pathological Biochemistry, Glasgow Royal Infirmary) for a one-year study of anbnormalities of lipoprotein metabolism in proteinuria and its role in cardiovascular risk and the progression of chronic renal failure.
£2,960 to Drs Russell L. Woods & Stephen J. Tregear (Vision Sciences, Glasgow Caledonian University) to purchase a camera attachment for use in screening for diabetic retinopathy using cone-specific perimetry.
£25,963 to Dr Deborah Dewar (Wellcome Surgical Unit, Glasgow University) for a one-year in vitro study using organotypic slice cultures of presynaptic protein damage after ischaemia.
£78,82 to Dr Helen Lyall (Obstetrics & Gynaecology, Glasgow Royal Infirmary), Professor Iain T. Cameron (Obstetrics & Gynaecology, Queen Mother's Hospital Glasgow), Dr John R. Petrie & Professor John M. Connell (Medicine & Therapeutics, Western Infirmary Glasgow) and Dr Gwynn W. Gould (Biochemistry & Molecular Biology, Glasgow University) for a two-year study of insulin as a vascular hormone in women with polycystic ovary syndrome.
Awards in 1995-96£56,145 to Professor Janet M. Allen (Biochemistry & Molecular Biology, Glasgow University) for a study of neuronal differentiation induced by the neuropeptide pituitary adenylyl cyclase activating peptide (PACAP).
£31,967 to Dr Margaret M. Harnett (Immunology, Glasgow University) and Professor Roger D. Sturrock (Centre for Rheumatic Diseases, Glasgow Royal Infirmary) to investigate whether lesions in phospholipase A2 signalling in FAS and TNF-mediated T-cell apoptosis break periperal tolerance, inducing autoimmune disease such as rheumatoid arthritis.
Awards in 1994-95£100,000 as a capital grant to Professors Henry Dargie (Medicine & Therapeutics), Ian McGrath (Physiology) and Stuart Cobbe (Medical Cardiology, Glasgow Royal Infirmary) all of Glasgow University, to fund the provision of a suite of five research laboratories as part of the University's Clinical Research Initiative into cardiovascular disease.
£7,647 to Dr Jeremy Bagg & Miss Kirsty Roy (Glasgow Dental School), Dr Edward A. Follett (HIV/Hepatitis Laboratory) and Dr David J. Goldberg (Scottish Centre for Infection & Environmental Health, Ruchill Hospital, Glasgow) for a one-year study aimed at optimising specimen collection methods for the detection of hepatitis C in saliva.
£57,799 to Professor Janet M. Alllen (Molecular Medicine, Glasgow University) over 23 months for studies on the mechanism of Fc(gamma)RI internalisation of antigen.
£36,063 to Dr Karen Horsburgh (Wellcome Surgical Institute & Hugh Fraser Laboratories, Glasgow University) for a one-year study of alterations in protein kinase C and amyloid precursor protein in human head injury and stroke.
£56,805 over two years to Professor Alex Elliott & Mr Keith McKellar (Clinical Physics, Glasgow University), Professor James McKillop (Medicine), Dr Brian Neilly (Nuclear Medicine) and Dr Curtis Gemmell (Biochemistry, Glasgow Royal Infirmary) for a study involving novel radiopharmaceutical approaches to inflammation imaging.
The Mrs Jean V. Baxter Medical Research Fellowship 1995-97 was awarded to Dr Martin McIntyre (Medicine & Therapeutics, Western Infirmary Glasgow) for a study of endothelial nitric oxide deficiency in cardiovascular disease and its consideration as a target for genetic manipulation.
Awards in 1993-94£62,170 over two years to Professor Iain T. Cameron & Dr Fiona Lyall (Obstetrics & Gynaecology, Glasgow University) & Dr Anthony P. Davenport (Cambridge University) for an investigation of endothelin receptor subtypes in human endometrium and their role in the pathophysiology of menorrhagia.
£89,850 over two and a half years to Drs Hugh J. Willison & G. Paterson (Neurology, Glasgow University) and colleagues in Cambridge, London and Texas, for a study involving combinatorial library cloning of anti-ganglioside antibodies from autoimmune neuropathy patients.
£62,850 over two years to Dr Carol E. Chu (Duncan Guthrie Institute of Medical Genetics, Yorkhill Hospital, Glasgow) & Professor J.M. Connor (Medical Genetics, Glasgow University) for a clinical and molecular genetic analysis of Turner's Syndrome, correlating genotype to phenotype.
The Cruden Medical Research Scholarship was awarded to Dr Kevin W. Robertson (Surgery, Glasgow Royal Infirmary University NHS Trust) to study the role of EGF and C-ERBB-2 receptors in determining the invasive potential of breast cancer.
Awards in 1992-93£73,000 over two years to Dr David I. Stott (Bacteriology & Immunology, Glasgow University) for a study of the genetic origins and control of expression of autoaggressive B-cell clones in systemic lupus erythematosus.
£60,464 to Professor Colin S. McArdle, Mr Barry Kelly & Dr Wilson J. Angerson (Surgery, Glasgow Royal Infirmary) for a two-year investigation of the detection of 'occult' liver metastases using duplex/colour Doppler ultrasonography.
Professor William R. Lee (Ophthalmology & Pathology) & Dr John G. Edwards (Cell Biology, Glasgow University) to investigate the familial and autoimmune aspects of age-related macular degeneration.
£84,827 over three years to Dr Donald Bissett (Beatson Oncology Centre, Western Infirmary Glasgow) & Dr Robert Brown (Medical Oncology, Glasgow University) to study the role of p53 in resistance of tumours to the chemotherapeutic drug, cisplatin.
£55,280 to Dr John M.S. Bartlett, Dr D. Fenton-Lee & Professor Tim G. Cooke (Surgery, Glasgow Royal Infirmary), Dr Valerie Brunton (CRC Department for Medical Oncology) & Dr Brad Ozanne (Beatson Institute for Cancer Research, Glasgow) for a two-year study of the use of novel inhibitors of EGF receptor tyrosine kinase activity as potential therapeutic agents in the control of gastric cancer.
£105,793 over three years to Dr Anna F. Dominiczak & Professor John L. Reid (Medicine & Therapeutics, Glasgow University), Dr Marek H. Dominiczak (Biochemistry, Western Infirmary Glasgow) & Dr Christopher J.K. Packard, Professor James Shepherd & Dr Dairena Gaffney (Biochemistry, Royal Infirmary Glasgow) to investigate the biochemical, cellular and genetic characteristics of familial hypercholesterolaemia in the west of Scotland.
£54,014 over two years to Dr Donald M. Salter (Pathology, Edinburgh University) to investigate the potential of tenascin as a serological marker of arthritis and to assess its role in articular cartilage degeneration and repair.
The Mrs Jean V. Baxter Medical Research Fellowship 1993-95 was awarded to Dr Karen J. Horsburgh (Wellcome Surgical Institute & Hugh Fraser Laboratories, Glasgow University) for work on protein kinase and beta-amyloid protein deposition in human head injury and stroke.