Awards made during 1995-96
£100,000 as a capital grant to Professors John E. Fothergill & William Harris (Molecular & Cell Biology, Aberdeen University) for the cost of the SHERT laboratory in the Institute of Medical Sciences.
£68,548 to Professor Keith James (Surgery, Edinburgh University) for the development of recombinant bacillus-Guerin-expressing cytoking and adhesion molecule genes for use in bladder cancer therapy.
£53,841 to Drs Marilyn Moore and Andrew J. Leigh Brown (Centre for HIV Research, Edinburgh University) for a study of the role of cytokine production by macrophages in HIV disease progression.
£65,960 to Drs Sandrine Prost, Christopher O.C. Bellamy & David J. Harrison (Pathology, Edinburgh University) for a study aimed at ascertaining whether impaired DNA repair underlies hepatocarcinogenesis in chronic liver disease.
£56,145 to Professor Janet M. Allen (Biochemistry & Molecular Biology, Glasgow University) for a study of neuronal differentiation induced by the neuropeptide pituitary adenylyl cyclase activating peptide (PACAP).
£69,254 to Ms Susan White, Drs V. Jill Bubb & Alan R. Clarke and Professor Andrew H. Wyllie (Pathology, Edinburgh University) and Dr Deborah Fowlis (Centre for Genome Research, Edinburgh) for a study of APC function and dysfunction and its role in neoplasia and development.
£20,500 to Professor Andrew H. Wyllie (Pathology, Edinburgh University) for the isolation and identification of genes involved in apoptosis.
£55,411 to Professor John E. Fothergill and Dr William T. Melvin (Molcular & Cell Biology) and Dr Graeme I. Murray (Pathology, Aberdeen University) for a study of the activation and inhibition of matrix metalloproteinases (MMPs) in tumour invasion.
£58,482 to Drs Simon C. Riley and David C. Howe and Professor Andrew A. Calder (Obstetrics & Gynaecology, Edinburgh University) for a study of the role of matrix metalloproteinases in fetal membranes, decidua and placenta in the initiation of preterm labour.
£68,332 to Professor William J. Harris (Molecular & Cell Biology, Aberdeen University) for a study involving the identification of the repertoire of autoantigens recognised by B and T cells from patients with multiple sclerosis.
£31,967 to Dr Margaret M. Harnett (Immunology, Glasgow University) and Professor Roger D. Sturrock (Centre for Rheumatic Diseases, Glasgow Royal Infirmary) to investigate whether lesions in phospholipase A2 signalling in FAS and TNF-mediated T-cell apoptosis break periperal tolerance, inducing autoimmune disease such as rheumatoid arthritis.
£63,539 to Dr Malcolm P. Caulfield (Pharmacology & Clinical Pharmacology, Ninewells Hospital & Medical School, Dundee) for a study to define the transduction pathways inducing long-term synaptic depression and release of calcium from intracellular stores by investigating the metabotropic glutamate receptors in cerebellar Purkinje neurones.
£3,702 as a supplement to Dr David W. Rae (Cruden Medical Research Scholar 1995-96; Obstetrics & Gynaeology, Aberdeen) for his investigation of the mechanisms controlling dilatation of the human pregnant cervix using biochemical, biomechanical and magnetic resonance imaging techniques.
£12,363 as a supplement to Drs Michael W.H. Coughtrie (Biochemical Medicine) and John A. Mills (Reproductive Medicine Unit, Ninewells Hospital & Medical School, Dundee) for their investigation of the regulation by sulphation of steroid hormone activity in the human female reproductive tract and its relationship to infertility and early pregnancy loss.
The Mrs Jean V. Baxter Medical Research Fellowship 1996-98 was awarded to Dr Jonathan N. Berg (MRC Human Genetics Unit, Western General Hospital, Edinburgh) for an investigation of the activin-like receptor kinase I gene as a candidate for the hereditary haemorrhagic telangiectasia 2 locus.
The Cruden Medical Research Scholarship 1996-97 was awarded to Dr Robert C. Rintoul to work in the Respriratory Medicine Unit of Edinburgh Royal Infirmary on extracellular matrix regulation of cell growth, drug resistance and apoptosis in small cell lung cancer.